ANGPTL-4 induces diabetic retinal inflammation by activating Profilin-1
Q Lu, P Lu, W Chen, L Lu, Z Zheng - Experimental Eye Research, 2018 - Elsevier
Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age
adults, results in central vision loss that is caused by microvascular damage to the inner
lining of the back of the eye, the retina. The aim of this work was to assess the temporal
relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor,
and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway
(s) and upstream mediator (s) of ANGPTL-4 were then determined under high glucose (HG) …
adults, results in central vision loss that is caused by microvascular damage to the inner
lining of the back of the eye, the retina. The aim of this work was to assess the temporal
relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor,
and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway
(s) and upstream mediator (s) of ANGPTL-4 were then determined under high glucose (HG) …