Chronic pancreatitis, a comprehensive review and update. Part I: epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features
T Muniraj, HR Aslanian, J Farrell, PA Jamidar - Disease-a-month, 2014 - Elsevier
Chronic pancreatitis is an irreversible condition of the pancreas characterized by chronic
progressive pancreatic inflammation, fibrosis, and scarring resulting in loss of both exocrine
(acinar) and endocrine (islet cells) tissue. As the definition implies, it is the inflammation-led
fibrosis that culminates in CP. There are several conditions with exocrine insufficiency which
need to be distinguished from CP such as post-surgical changes and Shwachman–
Diamond Syndrome 1 (the second most common cause for exocrine pancreatic insufficiency …
progressive pancreatic inflammation, fibrosis, and scarring resulting in loss of both exocrine
(acinar) and endocrine (islet cells) tissue. As the definition implies, it is the inflammation-led
fibrosis that culminates in CP. There are several conditions with exocrine insufficiency which
need to be distinguished from CP such as post-surgical changes and Shwachman–
Diamond Syndrome 1 (the second most common cause for exocrine pancreatic insufficiency …