Androgen-mediated regulation of skeletal muscle protein balance

ML Rossetti, JL Steiner, BS Gordon - Molecular and cellular endocrinology, 2017 - Elsevier
ML Rossetti, JL Steiner, BS Gordon
Molecular and cellular endocrinology, 2017Elsevier
Androgens significantly alter muscle mass in part by shifting protein balance in favor of net
protein accretion. During various atrophic conditions, the clinical impact of decreased
production or bioavailability of androgens (termed hypogonadism) is important as a loss of
muscle mass is intimately linked with survival outcome. While androgen replacement
therapy increases muscle mass in part by restoring protein balance, this is not a
comprehensive treatment option due to potential side effects. Therefore, an understanding of …
Abstract
Androgens significantly alter muscle mass in part by shifting protein balance in favor of net protein accretion. During various atrophic conditions, the clinical impact of decreased production or bioavailability of androgens (termed hypogonadism) is important as a loss of muscle mass is intimately linked with survival outcome. While androgen replacement therapy increases muscle mass in part by restoring protein balance, this is not a comprehensive treatment option due to potential side effects. Therefore, an understanding of the mechanisms by which androgens alter protein balance is needed for the development of androgen-independent therapies. While the data in humans suggest androgens alter protein balance (both synthesis and breakdown) in the fasted metabolic state, a predominant molecular mechanism(s) behind this observation is still lacking. This failure is likely due in part to inconsistent experimental design between studies including failure to control nutrient/feeding status, the method of altering androgens, and the model systems utilized.
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