[HTML][HTML] Aberrant hepatic expression of PPARγ2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis

YL Zhang, A Hernandez-Ono, P Siri, S Weisberg… - Journal of Biological …, 2006 - ASBMB
Insulin-resistant apoB/BATless mice have hypertriglyceridemia because of increased
assembly and secretion of very low density apolipoprotein B (apoB) and triglycerides
compared with mice expressing only apoB (Siri, P., Candela, N., Ko, C., Zhang, Y., Eusufzai,
S., Ginsberg, HN, and Huang, LS (2001) J. Biol. Chem. 276, 46064-46072). Despite
increased very low density lipoprotein secretion, apoB/BATless mice have fatty livers. We
found that hepatic mRNA levels of key lipogenic enzymes, acetyl-CoA carboxylase, fatty …