Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice
VR Babaev, F Porro, MRF Linton, S Fazio, FE Baralle… - Atherosclerosis, 2008 - Elsevier
Atherosclerotic lesions are characterized by a profound alteration in the architecture of the
arterial intima, with a marked increase of fibronectin (FN) and the appearance of the
alternatively spliced FN variant containing the extra domain A (EDA). To analyze the role of
FN isoforms in atherosclerotic lesion formation we utilized mouse strains devoid of EDA
exon regulated splicing, which constitutively include (EDA+/+) or exclude (EDA−/−) the exon.
Both mutant mice had a 40% reduction in atherosclerotic lesions after the atherogenic-diet …
arterial intima, with a marked increase of fibronectin (FN) and the appearance of the
alternatively spliced FN variant containing the extra domain A (EDA). To analyze the role of
FN isoforms in atherosclerotic lesion formation we utilized mouse strains devoid of EDA
exon regulated splicing, which constitutively include (EDA+/+) or exclude (EDA−/−) the exon.
Both mutant mice had a 40% reduction in atherosclerotic lesions after the atherogenic-diet …