[HTML][HTML] Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity: different oligomers activate different signal transduction pathways
Acrp30/adiponectin is an adipocyte-derived serum protein with important roles in regulation
of lipid and glucose metabolism, but which of its isoforms are biologically active remains
controversial. We addressed this issue by first characterizing the structure of each individual
Acrp30 oligomer and the determinants responsible for multimer formation. Freeze etch
electron microscopy showed the trimer to exhibit a ball-and-stick-like structure containing a
large globular sphere, an extended collagen stalk, and a smaller sphere on the opposite …
of lipid and glucose metabolism, but which of its isoforms are biologically active remains
controversial. We addressed this issue by first characterizing the structure of each individual
Acrp30 oligomer and the determinants responsible for multimer formation. Freeze etch
electron microscopy showed the trimer to exhibit a ball-and-stick-like structure containing a
large globular sphere, an extended collagen stalk, and a smaller sphere on the opposite …