[HTML][HTML] Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation

S Chen, S Gulla, C Cai, SP Balk - Journal of Biological Chemistry, 2012 - ASBMB
Our previous findings indicated that androgen receptor (AR) phosphorylation at serine 81 is
stimulated by the mitotic cyclin-dependent kinase 1 (CDK1). In this report, we extended our
previous study and confirmed that Ser-81 phosphorylation increases during mitosis,
coincident with CDK1 activation. We further showed blocking cell cycle at G 1 or S phase did
not disrupt androgen-induced Ser-81 phosphorylation and AR-dependent transcription,
consistent with a recent report that AR was phosphorylated at Ser-81 and activated by the …