Genetics of Parkinson's disease
CM Lill - Molecular and cellular probes, 2016 - Elsevier
Almost two decades after the identification of SNCA as the first causative gene in
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a
substantial role in PD development, our knowledge of the genetic architecture underlying
this disease has vastly improved. Approximately 5–10% of patients suffer from a monogenic
form of PD where autosomal dominant mutations in SNCA, LRRK2, and VPS35 and
autosomal recessive mutations in PINK1, DJ-1, and Parkin cause the disease with high …
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a
substantial role in PD development, our knowledge of the genetic architecture underlying
this disease has vastly improved. Approximately 5–10% of patients suffer from a monogenic
form of PD where autosomal dominant mutations in SNCA, LRRK2, and VPS35 and
autosomal recessive mutations in PINK1, DJ-1, and Parkin cause the disease with high …