Are cyst-associated macrophages in polycystic kidney disease the equivalent to TAMs in cancer?
T Weimbs - Journal of the American Society of Nephrology, 2018 - journals.lww.com
Kidney injury leads to rapid infiltration of immune cells, presumably as a preemptive
measure to protect the organism from the danger of invading microbes that may exploit the
compromised epithelial barrier of injured tubules. Prominent among these infiltrating
immune cells are the macrophages that arrive early on the scene after injury. Previous
studies have shown that infiltrating macrophages are initially of the proinflammatory,
classically activated M1-like type that can exacerbate tubular injury due to their release of …
measure to protect the organism from the danger of invading microbes that may exploit the
compromised epithelial barrier of injured tubules. Prominent among these infiltrating
immune cells are the macrophages that arrive early on the scene after injury. Previous
studies have shown that infiltrating macrophages are initially of the proinflammatory,
classically activated M1-like type that can exacerbate tubular injury due to their release of …