[HTML][HTML] Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1
T Kamitani, K Kito, T Fukuda-Kamitani… - Journal of Biological …, 2001 - ASBMB
NEDD8 is a ubiquitin-like protein that controls vital biological events through its conjugation
to cullin family members. Recently, we identified a negative regulator of the NEDD8
conjugation system, NUB1, which interacts with NEDD8 and down-regulates NEDD8
expression post-transcriptionally (Kito, K., Yeh, ETH, and Kamitani, T.(2001) J. Biol. Chem.
276, 20603–20609). Here, we show that NUB1 possesses a ubiquitin-like domain at the N-
terminal region and binds to S5a of the 19 S proteasome activator (PA700). A GST pull …
to cullin family members. Recently, we identified a negative regulator of the NEDD8
conjugation system, NUB1, which interacts with NEDD8 and down-regulates NEDD8
expression post-transcriptionally (Kito, K., Yeh, ETH, and Kamitani, T.(2001) J. Biol. Chem.
276, 20603–20609). Here, we show that NUB1 possesses a ubiquitin-like domain at the N-
terminal region and binds to S5a of the 19 S proteasome activator (PA700). A GST pull …