[HTML][HTML] In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans1
CA Allister, L Liu, CA Lamendola, CM Craig… - Journal of lipid …, 2015 - ASBMB
Indirect evidence suggests that impaired triglyceride storage in the subcutaneous fat depot
contributes to the development of insulin resistance via lipotoxicity. We directly tested this
hypothesis by measuring, in vivo, TG synthesis, de novo lipogenesis (DNL), adipocyte
proliferation, and insulin suppression of lipolysis in subcutaneous adipose tissue of BMI-
matched individuals classified as insulin resistant (IR) or insulin sensitive (IS). Nondiabetic,
moderately obese subjects with BMI 25–35 kg/m 2, classified as IR or IS by the modified …
contributes to the development of insulin resistance via lipotoxicity. We directly tested this
hypothesis by measuring, in vivo, TG synthesis, de novo lipogenesis (DNL), adipocyte
proliferation, and insulin suppression of lipolysis in subcutaneous adipose tissue of BMI-
matched individuals classified as insulin resistant (IR) or insulin sensitive (IS). Nondiabetic,
moderately obese subjects with BMI 25–35 kg/m 2, classified as IR or IS by the modified …