Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance
RA Cox, AS Burke, DL Traber, DN Herndon… - Pulmonary …, 2007 - Elsevier
Burn patients often develop respiratory distress and ARDS several days after injury. An
ovine model allows experimental study of this problem. In sheep the injury is characterized
by intense acute inflammation in the trachea and bronchi from 3 to 48h after injury, with
accumulation of neutrophils, fibrin and other plasma proteins, and mucus in airway lumens.
We have carried out immunostaining for multiple cytokines in this model, including
interleukin-8 (IL-8), Interleukin-1 beta (IL-1β), interleukin-1 alpha (IL-1α), tumor necrosis …
ovine model allows experimental study of this problem. In sheep the injury is characterized
by intense acute inflammation in the trachea and bronchi from 3 to 48h after injury, with
accumulation of neutrophils, fibrin and other plasma proteins, and mucus in airway lumens.
We have carried out immunostaining for multiple cytokines in this model, including
interleukin-8 (IL-8), Interleukin-1 beta (IL-1β), interleukin-1 alpha (IL-1α), tumor necrosis …