Reprogramming tumor blood vessels for enhancing immunotherapy
M Schmittnaegel, M De Palma - Trends in cancer, 2017 - Elsevier
Angiogenic blood vessels contribute to generating an immunosuppressive tumor
microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming
of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T
cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other
cancer immunotherapies.
microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming
of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T
cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other
cancer immunotherapies.