[HTML][HTML] Transcriptional control of adipocyte formation

SR Farmer - Cell metabolism, 2006 - cell.com
Cell metabolism, 2006cell.com
A detailed understanding of the processes governing adipose tissue formation will be
instrumental in combating the obesity epidemic. Much progress has been made in the last
two decades in defining transcriptional events controlling the differentiation of mesenchymal
stem cells into adipocytes. A complex network of transcription factors and cell-cycle
regulators, in concert with specific transcriptional coactivators and corepressors, respond to
extracellular stimuli to activate or repress adipocyte differentiation. This review summarizes …
A detailed understanding of the processes governing adipose tissue formation will be instrumental in combating the obesity epidemic. Much progress has been made in the last two decades in defining transcriptional events controlling the differentiation of mesenchymal stem cells into adipocytes. A complex network of transcription factors and cell-cycle regulators, in concert with specific transcriptional coactivators and corepressors, respond to extracellular stimuli to activate or repress adipocyte differentiation. This review summarizes advances in this field, which constitute a framework for potential antiobesity strategies.
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