[HTML][HTML] Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation

JK Sethi, AJ Vidal-Puig - Journal of lipid research, 2007 - ASBMB
This review focuses on adipose tissue biology and introduces the concept of adipose tissue
plasticity and expandability as key determinants of obesity-associated metabolic
dysregulation. This concept is fundamental to our understanding of adipose tissue as a
dynamic organ at the center of nutritional adaptation. Here, we summarize the current
knowledge of the mechanisms by which adipose tissue can affect peripheral energy
homeostasis, particularly in the context of overnutrition. Two mechanisms emerge that …