Obesity therapy: altering the energy intake-and-expenditure balance sheet

VEF Crowley, GSH Yeo, S O'Rahilly - Nature reviews Drug discovery, 2002 - nature.com
VEF Crowley, GSH Yeo, S O'Rahilly
Nature reviews Drug discovery, 2002nature.com
Obesity is associated with numerous health complications, which range from non-fatal
debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as
coronary heart disease, diabetes and certain cancers. The psychological consequences of
obesity can range from lowered self-esteem to clinical depression. Despite the high
prevalence of obesity and the many advances in our understanding of how it develops,
current therapies have persistently failed to achieve long-term success. This review focuses …
Abstract
Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.
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