Differential effects of amphetamine on food and water intake in rats with lateral hypothalamic lesions.

HJ Carlisle - Journal of Comparative and Physiological Psychology, 1964 - psycnet.apa.org
HJ Carlisle
Journal of Comparative and Physiological Psychology, 1964psycnet.apa.org
Amphetamine sulphate produced significantly greater depression of food intake in normal
rats than in rats with lateral hypothalamic lesions, suggesting that amphetamine reduces
food intake by inhibiting the lateral hypothalamus. The 2 groups did not differ significantly
with respect to the action of amphetamine on water intake (suggesting different central sites
of action of this drug for food and water intake) or with respect to water intake following
injections of chlorpromazine HCI or neostigmine methylsulfate.(22 ref.)(PsycInfo Database …
Abstract
Amphetamine sulphate produced significantly greater depression of food intake in normal rats than in rats with lateral hypothalamic lesions, suggesting that amphetamine reduces food intake by inhibiting the lateral hypothalamus. The 2 groups did not differ significantly with respect to the action of amphetamine on water intake (suggesting different central sites of action of this drug for food and water intake) or with respect to water intake following injections of chlorpromazine HCI or neostigmine methylsulfate.(22 ref.)(PsycInfo Database Record (c) 2023 APA, all rights reserved)
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