Leptin replacement alters brain response to food cues in genetically leptin-deficient adults

K Baicy, ED London, J Monterosso… - Proceedings of the …, 2007 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2007National Acad Sciences
A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin
replacement to three adults with this mutation normalized body weight and eating behavior.
Because the neural circuits mediating these changes were unknown, we paired functional
magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During
viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked
to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked …
A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.
National Acad Sciences