A time to press reset and regenerate cardiac stem cell biology

JA Epstein - JAMA cardiology, 2019 - jamanetwork.com
In 2001, a research team published 2 high-profile reports1, 2 suggesting that bone marrow
could regenerate the heart and new myocytes are formed in the human heart at a substantial
and surprising rate. The articles upended existing dogma and contradicted years of rigorous
analysis. Researchers struggled to reproduce the findings with limited success, and Nature
took the unusual step of publishing 3 separate negative studies in 2003 and 2004
suggesting that bone marrow could not regenerate myocardium. 3-5 Other researchers …