Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial

BV Howard, L Van Horn, J Hsia, JAE Manson… - Jama, 2006 - jamanetwork.com
ContextMultiple epidemiologic studies and some trials have linked diet with cardiovascular
disease (CVD) prevention, but long-term intervention data are needed. ObjectiveTo test the
hypothesis that a dietary intervention, intended to be low in fat and high in vegetables, fruits,
and grains to reduce cancer, would reduce CVD risk. Design, Setting, and
ParticipantsRandomized controlled trial of 48 835 postmenopausal women aged 50 to 79
years, of diverse backgrounds and ethnicities, who participated in the Women's Health …