[HTML][HTML] Hypertriglyceridemia and cardiovascular risk: a cautionary note about metabolic confounding

AD Sniderman, P Couture, SS Martin, J DeGraaf… - Journal of lipid …, 2018 - ASBMB
Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C)
is the conventional tool to measure LDLs. Multiple epidemiological studies, including a
series of genetically based analyses, have demonstrated that cardiovascular risk is related
to triglycerides independently of LDL-C, and this has led to a series of new therapeutic
agents designed specifically to reduce plasma triglycerides. The triglyceride hypothesis
posits that increased levels of triglycerides increase cardiovascular risk and decreasing …