[HTML][HTML] The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the …
C Huang, GW Wong, N Ghildyal, MF Gurish… - Journal of Biological …, 1997 - ASBMB
Mouse mast cell protease (mMCP) 7 is a tryptase of unknown function expressed by a
subpopulation of mast cells that reside in numerous connective tissue sites. Because
enzymatically active mMCP-7 is selectively released into the plasma of V3 mastocytosis
mice undergoing passive systemic anaphylaxis, we used thisin vivo model system to identify
a physiologic substrate of the tryptase. Plasma samples taken from V3 mastocytosis mice
that had been sensitized with immunoglobulin (Ig) E and challenged with antigen were …
subpopulation of mast cells that reside in numerous connective tissue sites. Because
enzymatically active mMCP-7 is selectively released into the plasma of V3 mastocytosis
mice undergoing passive systemic anaphylaxis, we used thisin vivo model system to identify
a physiologic substrate of the tryptase. Plasma samples taken from V3 mastocytosis mice
that had been sensitized with immunoglobulin (Ig) E and challenged with antigen were …