Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma
CL Chen, SD Wang, ZY Zeng, KJ Lin, ST Kao… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: Serine proteases such as mast cell tryptase and certain allergens are
important in the pathogenesis of allergic inflammation of asthma. OBJECTIVE: We sought to
investigate the effects of serine protease inhibitors nafamostat mesilate (FUT), gabexate
mesilate (FOY), and ulinastatin (UTI) on airway inflammation in a mouse model of allergic
asthma. METHODS: BALB/c mice were sensitized to Dermatophagoides pteronyssinus (Der
p) and intratracheally challenged with Der p (0.5 mg/mL). Therapeutic doses of FUT (0.0625 …
important in the pathogenesis of allergic inflammation of asthma. OBJECTIVE: We sought to
investigate the effects of serine protease inhibitors nafamostat mesilate (FUT), gabexate
mesilate (FOY), and ulinastatin (UTI) on airway inflammation in a mouse model of allergic
asthma. METHODS: BALB/c mice were sensitized to Dermatophagoides pteronyssinus (Der
p) and intratracheally challenged with Der p (0.5 mg/mL). Therapeutic doses of FUT (0.0625 …