Pharmacological studies of FUT-175, nafamstat mesilate I. Inhibition of protease activity in in vitro and in vivo experiments
T AOYAMA, Y INO, M OZEKI, M ODA… - The Japanese Journal …, 1984 - jstage.jst.go.jp
T AOYAMA, Y INO, M OZEKI, M ODA, T SATO, Y KOSHIYAMA, S SUZUKI, M FUJITA
The Japanese Journal of Pharmacology, 1984•jstage.jst.go.jp\FUT-175, 6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate(nafamstat
mesilate), a novel synthetic protease-inhibiting agent, was studied to determine its in vitro
effects against various proteases and other enzymes, as well as to determine its in vivo
protease inhibitory effects. FUT-175 was found to inhibit, in an intense, specific and
reversible way, the enzyme activities of trypsin,
mesilate), a novel synthetic protease-inhibiting agent, was studied to determine its in vitro
effects against various proteases and other enzymes, as well as to determine its in vivo
protease inhibitory effects. FUT-175 was found to inhibit, in an intense, specific and
reversible way, the enzyme activities of trypsin,
Abstract
\FUT-175, 6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate(nafamstat mesilate), a novel synthetic protease-inhibiting agent, was studied to determine its in vitro effects against various proteases and other enzymes, as well as to determine its in vivo protease inhibitory effects. FUT-175 was found to inhibit, in an intense, specific and reversible way, the enzyme activities of trypsin,
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