[HTML][HTML] De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation
JM Collins, MJ Neville, KE Pinnick, L Hodson… - Journal of lipid …, 2011 - ASBMB
The primary products of de novo lipogenesis (DNL) are saturated fatty acids, which confer
adverse cellular effects. Human adipocytes differentiated with no exogenous fat
accumulated triacylglycerol (TG) in lipid droplets and differentiated normally. TG composition
showed the products of DNL (saturated fatty acids from 12: 0 to 18: 0) together with
unsaturated fatty acids (particularly 16: 1n-7 and 18: 1n-9) produced by elongation/
desaturation. There was parallel upregulation of expression of genes involved in DNL and in …
adverse cellular effects. Human adipocytes differentiated with no exogenous fat
accumulated triacylglycerol (TG) in lipid droplets and differentiated normally. TG composition
showed the products of DNL (saturated fatty acids from 12: 0 to 18: 0) together with
unsaturated fatty acids (particularly 16: 1n-7 and 18: 1n-9) produced by elongation/
desaturation. There was parallel upregulation of expression of genes involved in DNL and in …