[HTML][HTML] Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells
KL Zambell, MD Fitch, SE Fleming - The Journal of nutrition, 2003 - Elsevier
The objective of these experiments was to investigate the source of substrates used for lipid
synthesis and the pathways of substrate incorporation into lipids by epithelial cells of the
colon. Within replicates, cells were exposed to all treatments evaluated in that experiment.
By comparing the relative incorporation rates of several 14 C-labeled substrates into lipids,
acetate made a significantly larger carbon contribution to lipids than propionate, butyrate,
glucose or glutamine under the in vitro conditions utilized in this study. Other major carbon …
synthesis and the pathways of substrate incorporation into lipids by epithelial cells of the
colon. Within replicates, cells were exposed to all treatments evaluated in that experiment.
By comparing the relative incorporation rates of several 14 C-labeled substrates into lipids,
acetate made a significantly larger carbon contribution to lipids than propionate, butyrate,
glucose or glutamine under the in vitro conditions utilized in this study. Other major carbon …