[CITATION][C] Adipose tissue expandability, lipotoxicity and the metabolic syndrome

A Vidal-Puig - Endocrinología y Nutrición, 2013 - Elsevier
Whereas it is clear that obesity is a cardiovascular risk factor, the mechanisms linking
expansion of the adipose tissue (AT) to these co-morbilities is uncertain. We think that
inappropriate AT expandability and function is a key determinant of obesity-associated
metabolic complications by initiating a lipotoxic proinflammatory cascade that affects
essential metabolic organs. Thus, understanding the mechanisms that control AT expansion
and function may provide therapeutic approaches to optimise adipose lipid deposition and …