Inhibition of NF-κB by sodium salicylate and aspirin
E Kopp, S Ghosh - Science, 1994 - science.org
E Kopp, S Ghosh
Science, 1994•science.orgThe transcription factor nuclear factor-κB (NF-κB) is critical for the inducible expression of
multiple cellular and viral genes involved in inflammation and infection including interleukin-
1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and
aspirin inhibited the activation of NF-κB, which further explains the mechanism of action of
these drugs. This inhibition prevented the degradation of the NF-κB inhibitor, IκB, and
therefore NF-κB was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF …
multiple cellular and viral genes involved in inflammation and infection including interleukin-
1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and
aspirin inhibited the activation of NF-κB, which further explains the mechanism of action of
these drugs. This inhibition prevented the degradation of the NF-κB inhibitor, IκB, and
therefore NF-κB was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF …
The transcription factor nuclear factor-κB (NF-κB) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-κB, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-κB inhibitor, IκB, and therefore NF-κB was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-κB-dependent transcription from the Igκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
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