To better understand the clinical and pathologic features of end-stage, androgen-
independent carcinoma of the prostate (CaP), we performed rapid autopsies on 14 men who
died of progressive CaP and recorded relevant clinical data. The timing of tumor progression
varied widely. The median time to androgen independence was 2 years (range, 4 months to
13.6 years). The median survival after androgen independence was 1 year (range, 1 month
to 3.6 years). Because osseous metastases are prevalent in progressive CaP, up to 20 bone …