[HTML][HTML] GPR92 as a new G12/13-and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5
CW Lee, R Rivera, S Gardell, AE Dubin… - Journal of Biological …, 2006 - ASBMB
The signaling effects of lysophospholipids such as lysophosphatidic acid (LPA) are
mediated by G protein-coupled receptors (GPCRs). There are currently four LPA receptors
known as LPA 1–4. Genetic deletion studies have identified essential biological functions for
LPA receptors in mice. However, these studies have also revealed phenotypes consistent
with the existence of as yet unidentified receptors. Toward identifying new LPA receptors, we
have screened collections of GPCR cDNAs using reverse transfection and cell-based …
mediated by G protein-coupled receptors (GPCRs). There are currently four LPA receptors
known as LPA 1–4. Genetic deletion studies have identified essential biological functions for
LPA receptors in mice. However, these studies have also revealed phenotypes consistent
with the existence of as yet unidentified receptors. Toward identifying new LPA receptors, we
have screened collections of GPCR cDNAs using reverse transfection and cell-based …