Germ line mutations of the ubiquitin ligase cullin 7 (CUL7) are linked to 3-M syndrome and
Yakuts short stature syndrome, both of which are characterized by pre-and post-natal growth
retardation. CUL7 knock-out mice show placental and embryonic defects similar to
intrauterine growth retardation, suggesting a role of CUL7 in placentation. CUL7 was found
in this study to be highly expressed in first trimester invasive human placental villi as well as
in HTR8/SVneo and B6Tert cells, two cell lines derived from human first trimester trophoblast …