Experimental autoimmune encephalomyelitis in the common marmoset, a bridge between rodent EAE and multiple sclerosis for immunotherapy development

YS Kap, JD Laman, BA 't Hart - Journal of neuroimmune pharmacology, 2010 - Springer
YS Kap, JD Laman, BA 't Hart
Journal of neuroimmune pharmacology, 2010Springer
The attrition rate of new drugs for central nervous system diseases including multiple
sclerosis (MS) is very high. A widely recognized bottleneck in the selection of promising
central nervous system drug candidates from the development pipeline is the lack of
sufficiently predictive animal models. Here, we review how the experimental autoimmune
encephalomyelitis (EAE) model in the Neotropical primate “common marmoset” can help to
bridge the gap between rodent EAE models and MS. The EAE model in the marmoset …
Abstract
The attrition rate of new drugs for central nervous system diseases including multiple sclerosis (MS) is very high. A widely recognized bottleneck in the selection of promising central nervous system drug candidates from the development pipeline is the lack of sufficiently predictive animal models. Here, we review how the experimental autoimmune encephalomyelitis (EAE) model in the Neotropical primate “common marmoset” can help to bridge the gap between rodent EAE models and MS. The EAE model in the marmoset closely resembles MS in the clinical as well as pathological presentation and can be used for fundamental research into immunopathogenic mechanisms and for therapy development. We discuss recent insights arising from this model, both on novel therapeutics and immunopathogenesis.
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