All organs including the brain contain iron, and the proteins involved in iron uptake
(transferrin and transferrin receptor) and intracellular storage (ferritin). However, because
the brain resides behind a barrier and has a heterogeneous population of cells, there are
aspects of its iron management that are unique. Iron management, the timely delivery of
appropriate amounts of iron, is crucial to normal brain development and function.
Mismanagement of cellular iron can result not only in decreased metabolic activity but …