[HTML][HTML] How metabolites modulate metabolic flux
Highlights•Metabolites actively participate in regulating cellular metabolism.•Metabolite
intervention is common on all levels of enzyme regulation.•Knowledge of metabolite sensing
mechanisms is crucial for a systems understanding of metabolism.Adaptation to metabolic
needs and changing environments is a basic requirement of every living system. These
adaptations can be very quick and mild or slower but more drastic. In any case, cells have to
constantly monitor their metabolic state and requirements.In this article we review general …
intervention is common on all levels of enzyme regulation.•Knowledge of metabolite sensing
mechanisms is crucial for a systems understanding of metabolism.Adaptation to metabolic
needs and changing environments is a basic requirement of every living system. These
adaptations can be very quick and mild or slower but more drastic. In any case, cells have to
constantly monitor their metabolic state and requirements.In this article we review general …
Highlights
- Metabolites actively participate in regulating cellular metabolism.
- Metabolite intervention is common on all levels of enzyme regulation.
- Knowledge of metabolite sensing mechanisms is crucial for a systems understanding of metabolism.
Adaptation to metabolic needs and changing environments is a basic requirement of every living system. These adaptations can be very quick and mild or slower but more drastic. In any case, cells have to constantly monitor their metabolic state and requirements.
In this article we review general concepts as well as recent advances on how metabolites can regulate metabolic fluxes. We discuss how cells sense metabolite levels and how changing metabolite levels regulate metabolic enzymes on different levels, from specific allosteric regulation to global transcriptional regulation. We thereby focus on local metabolite sensing in mammalian cells and show that several major discoveries have only very recently been made.
Elsevier