Sepsis is a severe and dysregulated inflammatory response to infection characterized by
end-organ dysfunction distant from the primary site of infection. Development of acute kidney
injury (AKI) during sepsis increases patient morbidity, predicts higher mortality, has a
significant effect on multiple organ functions, is associated with an increased length of stay
in the intensive care unit, and hence consumes considerable healthcare resources. When
compared with AKI of nonseptic origin, septic AKI is characterized by a distinct …