Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids
R Thanissery, JA Winston, CM Theriot - Anaerobe, 2017 - Elsevier
The changing epidemiology of Clostridium difficile infection over the past decades presents
a significant challenge in the management of C. difficile associated diseases. The
gastrointestinal tract microbiota provides colonization resistance against C. difficile, and
growing evidence suggests that gut microbial derived secondary bile acids (SBAs) play a
role. We hypothesized that the C. difficile life cycle; spore germination and outgrowth,
growth, and toxin production, of strains that vary by age and ribotype will differ in their …
a significant challenge in the management of C. difficile associated diseases. The
gastrointestinal tract microbiota provides colonization resistance against C. difficile, and
growing evidence suggests that gut microbial derived secondary bile acids (SBAs) play a
role. We hypothesized that the C. difficile life cycle; spore germination and outgrowth,
growth, and toxin production, of strains that vary by age and ribotype will differ in their …