[HTML][HTML] F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for …
K Yumimoto, M Matsumoto, I Onoyama… - Journal of Biological …, 2013 - ASBMB
Background: Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that
plays key roles in tumor suppression and stem cell maintenance. Results: The transcription
factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion: Fbxw7
controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for
degradation. Significance: Fbxw7 is an important regulator of osteogenesis and
chondrogenesis. Although identification of substrates for an enzyme is a key step in …
plays key roles in tumor suppression and stem cell maintenance. Results: The transcription
factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion: Fbxw7
controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for
degradation. Significance: Fbxw7 is an important regulator of osteogenesis and
chondrogenesis. Although identification of substrates for an enzyme is a key step in …