Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice
Y Sun, T Tian, J Gao, X Liu, H Hou, R Cao, B Li… - Journal of …, 2016 - Elsevier
Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical
roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses
and the underlying mechanisms in response to metformin in C57BL/6 mice with
experimental autoimmune encephalomyelitis (EAE). Metformin reduced Th17 and increased
Treg cell percentages along with the levels of associated cytokines. Molecules involved in
cellular metabolism were altered in mice with EAE. Suppressed activation of mTOR and its …
roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses
and the underlying mechanisms in response to metformin in C57BL/6 mice with
experimental autoimmune encephalomyelitis (EAE). Metformin reduced Th17 and increased
Treg cell percentages along with the levels of associated cytokines. Molecules involved in
cellular metabolism were altered in mice with EAE. Suppressed activation of mTOR and its …