Requirement for Xist in X chromosome inactivation
GD Penny, GF Kay, SA Sheardown, S Rastan… - Nature, 1996 - nature.com
GD Penny, GF Kay, SA Sheardown, S Rastan, N Brockdorff
Nature, 1996•nature.comThe Xist gene has been proposed as a candidate for the X inactivation centre, the master
regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has
been supported solely by indirect evidence. Here we describe gene targeting of Xist, and
provide evidence for its absolute requirement in the process of X chromosome inactivation.
regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has
been supported solely by indirect evidence. Here we describe gene targeting of Xist, and
provide evidence for its absolute requirement in the process of X chromosome inactivation.
Abstract
The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.
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