A resource for cell line authentication, annotation and quality control
M Yu, SK Selvaraj, MMY Liang-Chu, S Aghajani… - Nature, 2015 - nature.com
M Yu, SK Selvaraj, MMY Liang-Chu, S Aghajani, M Busse, J Yuan, G Lee, F Peale, C Klijn…
Nature, 2015•nature.comCell line misidentification, contamination and poor annotation affect scientific reproducibility.
Here we outline simple measures to detect or avoid cross-contamination, present a
framework for cell line annotation linked to short tandem repeat and single nucleotide
polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will
enable our community to eradicate the use of misidentified lines and generate credible cell-
based data.
Here we outline simple measures to detect or avoid cross-contamination, present a
framework for cell line annotation linked to short tandem repeat and single nucleotide
polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will
enable our community to eradicate the use of misidentified lines and generate credible cell-
based data.
Abstract
Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.
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