[HTML][HTML] A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

P Ravassard, Y Hazhouz, S Pechberty… - The Journal of …, 2011 - Am Soc Clin Investig
P Ravassard, Y Hazhouz, S Pechberty, E Bricout-Neveu, M Armanet, P Czernichow…
The Journal of clinical investigation, 2011Am Soc Clin Investig
For decades, investigators have made numerous attempts to generate human pancreatic β
cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide
a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI,
Ravassard and colleagues report that this has finally been achieved successfully with a
multistep process that led to the generation of cells, which they termed EndoC-βH1 cells,
that secreted insulin in response to glucose challenge.
For decades, investigators have made numerous attempts to generate human pancreatic β cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI, Ravassard and colleagues report that this has finally been achieved successfully with a multistep process that led to the generation of cells, which they termed EndoC-βH1 cells, that secreted insulin in response to glucose challenge.
The Journal of Clinical Investigation