Rotavirus entry: a deep journey into the cell with several exits

CF Arias, D Silva-Ayala, S López - Journal of virology, 2015 - Am Soc Microbiol
CF Arias, D Silva-Ayala, S López
Journal of virology, 2015Am Soc Microbiol
Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young
children worldwide. These nonenveloped viruses enter cells using different types of
endocytosis and, depending on the virus strain, travel to different endosomal compartments
before exiting to the cytosolic space. In this Gem, we review the viral and cellular factors
involved in the different stages of a productive virus cell entry and share with the readers the
journey that we have taken into the cell to learn about virus entry.
Abstract
Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young children worldwide. These nonenveloped viruses enter cells using different types of endocytosis and, depending on the virus strain, travel to different endosomal compartments before exiting to the cytosolic space. In this Gem, we review the viral and cellular factors involved in the different stages of a productive virus cell entry and share with the readers the journey that we have taken into the cell to learn about virus entry.
American Society for Microbiology