Selected topics in the field of rotavirus immunity are reviewed focusing on recent
developments that may improve efficacy and safety of current and future vaccines.
Rotaviruses (RVs) have developed multiple mechanisms to evade interferon (IFN)-mediated
innate immunity. Compared to more developed regions of the world, protection induced by
natural infection and vaccination is reduced in developing countries where, among other
factors, high viral challenge loads are common and where infants are infected at an early …