[HTML][HTML] Rotavirus vaccines: recent developments and future considerations

J Angel, MA Franco, HB Greenberg - Nature reviews microbiology, 2007 - nature.com
Nature reviews microbiology, 2007nature.com
Two new vaccines have recently been shown to be safe and effective in protecting young
children against severe rotavirus gastroenteritis. Although both vaccines are now marketed
worldwide, it is likely that improvements to these vaccines and/or the development of future
generations of rotavirus vaccines will be desirable. This Review addresses recent advances
in our knowledge of rotavirus, the host immune response to rotavirus infection and the
efficacy and safety of the new vaccines that will be helpful for improving the existing rotavirus …
Abstract
Two new vaccines have recently been shown to be safe and effective in protecting young children against severe rotavirus gastroenteritis. Although both vaccines are now marketed worldwide, it is likely that improvements to these vaccines and/or the development of future generations of rotavirus vaccines will be desirable. This Review addresses recent advances in our knowledge of rotavirus, the host immune response to rotavirus infection and the efficacy and safety of the new vaccines that will be helpful for improving the existing rotavirus vaccines, or developing new rotavirus vaccines in the future.
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