Telomeres in the Clinic, Not on TV
M Armanios - Mayo Clinic Proceedings, 2018 - mayoclinicproceedings.org
Recent discoveries have extended the reach of telomere biology from the basic sciences
into the heart of clinical medicine. 1 Telomeres were discovered in a pond protozoan; their
basic biology has been dissected in model systems like maize, yeast, and mice. 2 In cultured
human cells, telomere length predicts the onset of the Hayflick limit, the finite replicative
potential of cells before they senesce, and the exogeneous expression of the telomerase
catalytic component, TERT, can bypass senescence. 3, 4 These early discoveries have led …
into the heart of clinical medicine. 1 Telomeres were discovered in a pond protozoan; their
basic biology has been dissected in model systems like maize, yeast, and mice. 2 In cultured
human cells, telomere length predicts the onset of the Hayflick limit, the finite replicative
potential of cells before they senesce, and the exogeneous expression of the telomerase
catalytic component, TERT, can bypass senescence. 3, 4 These early discoveries have led …