Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility
of observational studies to confounding and reverse causation. Objective To conduct a
Mendelian randomization study, using germline genetic variants as instrumental variables,
to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic
diseases. Data Sources Genomewide association studies (GWAS) published up to January …
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility
of observational studies to confounding and reverse causation. Objective To conduct a
Mendelian randomization study, using germline genetic variants as instrumental variables,
to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic
diseases. Data Sources Genomewide association studies (GWAS) published up to January …