Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome …
F Zielecki, M Weber, M Eickmann… - Journal of …, 2013 - Am Soc Microbiol
F Zielecki, M Weber, M Eickmann, L Spiegelberg, AM Zaki, M Matrosovich, S Becker…
Journal of virology, 2013•Am Soc MicrobiolInfections with human coronavirus EMC (HCoV-EMC) are associated with severe
pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome
coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human
airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated
antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly
more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize …
pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome
coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human
airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated
antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly
more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize …
Abstract
Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.
American Society for Microbiology