Oxygen sensing and homeostasis

NR Prabhakar, GL Semenza - Physiology, 2015 - journals.physiology.org
NR Prabhakar, GL Semenza
Physiology, 2015journals.physiology.org
The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen
levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs)
in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the
gas-messenger signaling mechanisms associated with oxygen sensing, as well as
transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen
homeostasis by HIFs and their relevance to physiology and pathology.
The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.
American Physiological Society