Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention
M Braddock, A Quinn - Nature reviews Drug discovery, 2004 - nature.com
M Braddock, A Quinn
Nature reviews Drug discovery, 2004•nature.comAbstract The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a
wide range of inflammatory responses in a number of cell types. Biological agents that target
IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new
classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-
1 pathway, are being investigated as new drugs for the management of inflammatory
disease. Such compounds will have wide utility in numerous inflammatory conditions.
wide range of inflammatory responses in a number of cell types. Biological agents that target
IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new
classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-
1 pathway, are being investigated as new drugs for the management of inflammatory
disease. Such compounds will have wide utility in numerous inflammatory conditions.
Abstract
The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a wide range of inflammatory responses in a number of cell types. Biological agents that target IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-1 pathway, are being investigated as new drugs for the management of inflammatory disease. Such compounds will have wide utility in numerous inflammatory conditions.
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