Epigenetics has been gaining great attention as a therapeutic target in cancer. The cancer
genome usually contains both hyper-and hypo-methylated genes to increase invasion,
proliferation and metastasis. These cells not only operate their own growth, but also develop
various strategies to escape from immune surveillance, and for this aim, regulatory T (Treg)
cells support the cancer-mediated immune suppression. The fate of Treg cells is mainly
controlled by DNA methylation within the promoter and intronic regions of Foxp3 gene …